An estimated 631K-827K viruses with zoonotic spillover potential exist in wildlife but only 7K are identified. Current surveillance detects only 10-15% of spillovers before human-to-human transmission. Coverage requires $1.5-2B/year; current spending is $300-400M/year ($1.1-1.7B shortfall). COVID-19 will cost $8-20T; prevention would cost $30B/year (250-700x ROI). Yet prevention receives 1/100th of pandemic response resources.